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Test Code NTBNP NT-proBNP

Important Note

Test subject to Medicare National Coverage Determination (NCD) B-type Natriuretic Peptide (BNP) Testing (L26375).


Immunometric Immunoassay


Description CPT Code
NT-BNP 83880


Specimen Information




Collect Vol

Submit Vol

Minimum Vol

Lithium Heparin (Green top) Plasma


4 mL 1 mL 0.5 mL 3 days
SST Serum Refrigerate 4 mL 1 mL 0.5 mL 3 days
*Green Microtainer     0.6 mL      

EDTA (lavender Top) tube is NOT acceptable.

*While a microtainer is an optional tube type in rare circumstances, it is not recommended.

Reference Range

NT-proBNP values less than 300 pg/ml have a 99% negative predictive value for excluding acute congestive heart failure. A diagnostic NT-proBNP cutoff of 900 pg/ml has been sug-gested in adults over 50 years of age in the absence of renal failure. A cutoff of 1200 pg/ml for patients with an eGFR less than 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute congestive failure.
The results of this assay can be falsely lowered due to the consumption of Biotin. Please instruct patients to discontinue the use of vitamins or supplements that contain Biotin 12 hours before blood collection.


Ortho Vitros

LOINC Code Information

Result Code Reporting Name LOINC Code
NTBNP NT Pro BNP 33762-6


Performing Location

University of Vermont Medical Center

Test Schedule / Analytical Time / Test Priority

Daily / 24 Hours / Available STAT



Is the UVMMC lab NY State Certified to perform this testing?  Yes/No