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HelpTest Code CNEI Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation Interpretation, Serum (Non-Orderable)
Specimen Required
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Useful For
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Interpretation for the Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation
Method Name
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Technical Interpretation
Reporting Name
Comprehensive Neuropathy Interp, SSpecimen Type
SerumSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Clinical Information
This evaluation detects autoantibodies associated with autoimmune and paraneoplastic neuropathies. The panel includes antibodies targeting peripheral nerve, dorsal root ganglia, and nodal/paranodal antigens, improving detection across diverse neuropathy phenotypes.
Reflex testing is performed to confirm and further characterize antibody reactivity, enhancing diagnostic sensitivity.
Appropriate for patients with subacute or progressive neuropathy, atypical or asymmetric presentations, autonomic involvement, or suspected immune-mediated or paraneoplastic etiologies.
Reference Values
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
An interpretive report will be provided.
Interpretation
The presence of specific autoantibodies and/or combinations of antibodies in this panel provides supportive evidence of an immune-mediated peripheral neuropathy. However, these results must be interpretated in the appropriate clinical context. A negative result does not exclude the possibility of an immune mediated peripheral neuropathy.
Cautions
Negative results do not exclude a diagnosis of an immune-mediated neuropathy. Autoantibody results should always be correlated with the clinical phenotype. The use of immunotherapy prior to sample collection may result in either false positive or false negative results.
The use of immunotherapy prior to sample collection may result in either false-positive or false-negative results.
Clinical Reference
1. Shelly S, Klein CJ, Dyck PJB, et al. Neurofascin-155 immunoglobulin subtypes: Clinicopathologic associations and neurologic outcomes. Neurology. 2021;97(24): e2392-e2403
2. Dubey D, Honorat JA, Shelly S, et al. Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates. Neurol Neuroimmunol Neuroinflamm. 2020;7(4)e771
3. Paramasivan NK, Basal E, LaFrance-Corey RG, et al. Clinical Insights Into CASPR1 and CASPR1/contactin-1 complex autoimmune nodopathies. Neurology. 2026;106(5):e214403. doi:10.1212/WNL.0000000000214403
4. Klein CJ, Triplett JD, Murray DL, et al. Optimizing anti-myelin-associated glycoprotein and IgM-gammopathy testing for neuropathy treatment evaluation. Neurology. 2024;103(11):e210000. doi:10.1212/WNL.0000000000210000
5. Dubey D, Lennon VA, Gadoth A, et al. Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases. Neurology. 2018;90(2):e103-e110. doi:10.1212/WNL.0000000000004803
6. Dubey D, Jitprapaikulsan J, Bi H, et al. Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome. Neurology. 2019;93(20):e1873-e1880. doi:10.1212/WNL.0000000000008472
7. Dubey D. Autoimmune neuromuscular disorders associated with neural antibodies. Continuum (Minneap Minn). 2024;30(4):1136-1159. doi:10.1212/CON.0000000000001461
Method Description
An interpretation based on test results is generated by the laboratory information system.
Day(s) Performed
Monday through Sunday
Report Available
8 to 12 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableLOINC Code Information
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621106 | Comprehensive Neuropathy Interp, S | 69048-7 |
| 624190 | IFA Notes | 48767-8 |