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Test Code Cortisol Stimulation Test Cortisol Stimulation Test

Important Note

This is orderable as an inpatient or through the Infusion Center.

Adrenal Corticotropin stimulation tests the ability of the adrenal gland to produce cortisol upon administration of intravenous Cortrosyn, a synthetic ACTH analog. This test is used to assess adrenal function and can differentiate primary from secondary adrenal insufficiency. Adverse reactions are very rare. ACTH is contraindicated in patients with elveated intracranial pressure.

Specimen Information

Patient Should be fasting.

Draw initial baseline and then again at 30 minutes and 60 minutes post dose.

Order: Cortisol, Stimulation Baseline  , Cortisol, Stimulation 30 Minutes,  Cortisol, Stimulation 60 Minutes

See Cortisol (LAB61) for collection instructions.

Reference Range

 Baseline 7-25 µg/dL

 Minimal Response: ≥18 µg/dL

 Usual Response: 30 to 50 µg/dL increase, peaks at 30-60 minutes

Interpretation

Patients with primary adrenal insufficiency have low baseline Cortisol levels and show little or no response to Cotrosyn. Patients receiving suppressive doses of steroids usually show an inadequate or absent response as well. Contact the Pathologist for further interpretation